The canonical method to estimate the causal effect of a continuous exposure on a continuous outcome using an?instrumental variable (IV)?for?one-sample MR.

在單樣本孟德爾隨機(jī)化（MR）中，使用工具變量（IV）來估計連續(xù)暴露對連續(xù)結(jié)局的因果效應(yīng)的標(biāo)準(zhǔn)方法。

For this method to provide a valid causal estimate of the exposure on the outcome,?genetic variants?must satisfy the?MR?assumptions and the model describing the association between the?genetic variant?and outcome must be correctly specified.

要使這種方法對暴露因素對結(jié)局的影響提供有效的因果估計，遺傳變異必須滿足孟德爾隨機(jī)化（MR）假設(shè)，且描述遺傳變異與結(jié)局之間關(guān)聯(lián)的模型必須正確設(shè)定。