130篇文章 · 324604字 · 29人關(guān)注
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文獻(xiàn)學(xué)習(xí)133--Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction1. FMO3 Induces FoxO1 via Its Product, TMAO FMO3在體內(nèi)的作用機(jī)制復(fù)雜，難以進(jìn)行機(jī)制研究。因此作者...
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文獻(xiàn)學(xué)習(xí)132--ISR Couples Mitochondrial Protein Translation With Oxidative Stress Control整合應(yīng)激反應(yīng) 1. Ischemia/Reperfusion Is Associated With Decreased Protein Synt...
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文獻(xiàn)學(xué)習(xí)131--IDO1 inhibitors block septic cytokine storm by suppressing the IDO1-AHR-CYP1A1 axis1. IDO1 was closely associated with the cytokine storm phase of sepsis I...
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文獻(xiàn)學(xué)習(xí)130--內(nèi)皮細(xì)胞IDO1通過Kyn調(diào)節(jié)心梗的心臟功能1. Upregulation of IDO Activity After MI Alters Cardiac Function and Rem...
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文獻(xiàn)學(xué)習(xí)129--GDF15 antagonism limits severe heart failure and prevents cardiac cachexia1. Mice lacking functional PPP1R15A exhibit left ventricular dilated car...
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文獻(xiàn)學(xué)習(xí)128--GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance1. GDF15 Is Induced in Inflammatory Conditions Sepsis患者(病毒感染、細(xì)菌感染、細(xì)菌病毒感染...
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文獻(xiàn)學(xué)習(xí)127--PHGDH介導(dǎo)的內(nèi)皮代謝驅(qū)動(dòng)glioblastoma對(duì)CAR-T免疫治療的耐受磷酸甘油酸脫氫酶（PHGDH）是絲氨酸合成途徑中的關(guān)鍵限速酶，催化3-磷酸甘油酸轉(zhuǎn)化為3-磷酸羥基丙酮酸，同時(shí)將NAD?還原為NADH。 1. ...
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文獻(xiàn)學(xué)習(xí)126--Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence1. p53 Lys120 Acetylation Is a Key Regulator of Endothelial Cell Senesce...
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文獻(xiàn)學(xué)習(xí)125--表觀水平靶向NPM1通過重編程修復(fù)性巨噬細(xì)胞代謝促進(jìn)心梗后心臟修復(fù)心肌梗死（MI）不僅會(huì)導(dǎo)致顯著的心肌細(xì)胞功能喪失，還會(huì)引發(fā)廣泛的炎癥反應(yīng)。適度的炎癥有助于清除細(xì)胞碎片并啟動(dòng)心肌修復(fù)，但過度炎癥會(huì)破壞可挽救的心...
